Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,571 – 6,585 of 60,541 results

6,571

Medchemexpress LLC M77976 10mM 1mL | 394237-61-7 | 1 ML

M77976 is a small-molecule, ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) supplied as a 10 mM solution in DMSO (1 mL) for research use. It shows enzymatic activity (IC50 648 μM) and cellular activity (HCT-116 GI50 33.3 μM), with chemical formula C17H16N2O3 and molecular weight 296.32.

Specific ATP-competitive inhibition of PDK4 (IC50 648 μM).
Measurable cellular activity in HCT-116 cells (GI50 33.3 μM).
High purity suitable for research (99.4%).
Provided as a 10 mM solution in DMSO, 1 mL volume.
High solubility in DMSO (250 mg/mL) and compatible with common in vivo vehicles.
Stable when stored under recommended conditions for powder and solution.

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6,572

Cayman Chemical IMR-1A, Purity: ≥95%, CAS: 331862-41-0, 100 mg

An inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of IMR-1; binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CSL transcription factor; increases multiciliation in primary choroid plexus cancer cells at 25 µM

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6,573

Medchemexpress LLC 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium | 51023-76-8 | MFCD00007485 | 94.4% | C17H12N2Na2O7S3 | 10MG

4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium is a fluorescent stilbene-derived dye and membrane probe used in cellular labeling and transport studies. It reacts covalently with proteins via its isothiocyanate group and is applied to visualize retrograde axonal transport, label antibodies, and stain whole cells; it also modulates anion permeability and Na,K-ATPase activity.

Fluorescent stilbene dye for cell and membrane staining.
Isothiocyanate group enables covalent labeling of proteins.
Suitable for demonstrating retrograde axonal transport.
Useful for studying anion transport and Na,K-ATPase activity.
Provided as a water-soluble disodium salt for biological use.
Available in small research pack sizes for laboratory studies.

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6,574

Cayman Chemical 4-Aminophenylphosphorylcholine, Purity: ≥95%, CAS: 102185-28-4, 5 mg

A probe that can be conjugated to sepharose in order to generate an adsorbent for use in affinity precipitation experiments

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6,575

Medchemexpress LLC (R)-INCB054329 | 1628607-63-5 | 98.9% | 348.36 g·mol⁻¹ | C19H16N4O3 | 5 MG

(R)-INCB054329 is the R-enantiomer of INCB054329, a potent BET bromodomain inhibitor used as an experimental control in biochemical and cellular research. Supplied as a powder for research use, it has molecular formula C19H16N4O3 and molecular weight 348.36 g·mol⁻1. Typical package sizes range from 1 mg to 100 mg, and analytical documentation (COA/LCMS) is available from the supplier.

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6,576

TARGETMOL CHEMICALS INC ALW-II-49-7 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase with an EC50 value of 40 nM in cell. purity: 99%

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6,577

Cayman Chemical ML-202, Purity: ≥98%, CAS: 1221186-52-2, 10 mg

A PKM2 activator; induces PMK2 activation in a cell-free assay (AC50 = 73 nM)

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6,578

Cayman Chemical Terpineol, Purity: ≥90% (mixture of isomers), CAS: 8000-41-7, 10 g

A monoterpene alcohol with diverse biological activities; this product is a mixture of α-, β-, and γ-terpineol

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6,579

AdipoGen Palbociclib (25 mg)

Chemical. CAS: 571190-30-2. Formula: C24H29N7O2. MW: 447.53. Palbociclib is a potent and selective inhibitor of CDK4 (IC50=11nM) and CDK6 (IC50=16nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases. It exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures and displays in vivo efficacy against various advanced stage human tumor xenografts in mice. It inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models. Induces autophagy and senescence in AGS gastric cancer cells. It is a clinically useful breast cancer agent. In addition cell cycle inhibitors have been shown to boost tumor immunogenicity.

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6,580

Medchemexpress LLC Noradrenalone hydrochloride | 5090-29-9 | MFCD00522692 | 1g

Noradrenalone impurity 1 hydrochloride is an impurity of Noradrenalone

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6,581

Medchemexpress LLC EphB4 Mouse HEK293 2ug

Ephb4 Protein a receptor tyrosine kinase plays a critical role in angiogenesis and development Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis inhibiting tumor growth and managing cardiovascular complications EphB4 Protein Mouse (HEK293 His) is the recombinant mouse-derived EphB4 protein expressed by HEK293 with C-His labeled tag

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6,582

Medchemexpress LLC Ibrutinib impurity 5 | 936563-97-2 | MFCD28385226 | 10mg

Ibrutinib Impurity 5 ((S)-Ibrutinib) is an impurity of Ibrutinib (HY-10997)

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6,583

Selleck Chemical LLC MS8709 E1974-25MG

MS8709 (EX-A11295) is a first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader that induces G9a/GLP degradation in a concentration time and ubiquitin-proteasome system (UPS)-dependent manner and does not alter the mRNA expression of G9a/GLP over other methyltransferases It displays superior cell growth inhibition in prostate leukemia and lung cancer cells over parent G9a/GLP inhibitors

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6,584

TARGETMOL CHEMICALS INC RELUGOLIX 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Relugolix (RVT-601) is an orally available non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist with potential antineoplastic activity. Relugolix competitively binds to and blocks the GnRH receptor in the anterior pituitary gland which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes. Since testosterone is required to sustain prostate growth reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. purity: 99%

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6,585

Medchemexpress LLC HY-126972A 5mg Medchemexpress, RI(dl)-2 (TFA) CAS: Purity:>98%

Medchemexpress, HY-126972A 5mg RI(dl)-2 (TFA) CAS: RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Bioactive Small Molecules

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Medchemexpress LLC M77976 10mM 1mL | 394237-61-7 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium | 51023-76-8 | MFCD00007485 | 94.4% | C17H12N2Na2O7S3 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (R)-INCB054329 | 1628607-63-5 | 98.9% | 348.36 g·mol⁻¹ | C19H16N4O3 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Noradrenalone hydrochloride | 5090-29-9 | MFCD00522692 | 1g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EphB4 Mouse HEK293 2ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ibrutinib impurity 5 | 936563-97-2 | MFCD28385226 | 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-126972A 5mg Medchemexpress, RI(dl)-2 (TFA) CAS: Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More