Bioactive Small Molecules
Apexbio Technology LLC Mildronate, 50mg. Cas: 76144-81-5 MFCD: MFCD00876389. GBB hydroxylase inhibitor
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC CHIR-99021 (CT99021), 100mg. Cas: 252917-06-9 MFCD: MFCD11846251. GSK-3 inhibitor, Cell-permeable, ATP-competitive
CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3) and 6.7 nM (GSK-3). Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC AEBSF.HCl, 100mg. Cas: 30827-99-7 MFCD: MFCD00132962. Serine protease inhibitor
AEBSF is a broad spectrum, irreversible inhibitor of serine proteases [1].AEBSF is a covalently binding inhibitor of proteases, including trypsin, chymotrypsin, plasmin and thrombin. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC KU-60019, 50mg. Cas: 925701-49-1 MFCD: MFCD18384974. ATM kinase inhibitor,potent and selective
KU-60019 is a selective inhibitor of the Ataxia telangiectasia (A-T) mutated (ATM) protein with an IC50 value of 6.3 nM. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC hyPerFUsion™ high-fidelity DNA polymerase, 100U
hyPerFUsion™ high-fidelity DNA polymerases are composed of a DNA-binding domain fused to a Pyrococcus-like proofreading polymerase. Because of this, hyPerFUsion™ DNA polymerases produce PCR products with very high speed and accuracy. Also, hyPerFUsion™ DNA polymerases are tolerant of various inhibitors, allowing for robust amplification with minimal optimization. hyPerFUsion™ DNA Polymerase is an ideal choice for cloning and can be used for long or difficult (GC-rich) amplicons. hyPerFUsion™ high-fidelity DNA polymerases have become the choice for even demanding applications like massively parallel high-throughput sequencing of whole genomes.High-Fidelity DNA Polymerases are important for applications in which the DNA sequence needs to be correct after amplification. Its unique structure, a novel Pyrococcus-like enzyme fused with a processivity-enhancing domain, increases fidelity and speed. Other sizes are available. Please inqury us for quote.
Selleck Chemical LLC NNMTi-E0133-5MG
NNMTi (Compound 1k NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1 2 M
Biotium Fluo-3, AM Ester, 1Mm In Anhydrous DMSO 1mL
Membrane-permeant AM ester form of Fluo-3 that can be loaded into cells via incubation. Because of the relatively low water solubility of the AM ester, Pluronic F-127, a mild detergent, is often used as a dispersing agent to facilitate dye loading. Fluo-3 AM ester itself does not bind Ca2 , but it is readily hydrolyzed to Fluo-3 by endogenous esterases once the dye is inside the cells. An important application of Fluo-3 AM ester is its use in high throughput drug screening. Properties: Orange red solid soluble in DMSO; Store -20°C and protect from light, especially when in solution; C51H50Cl2N2O23; MW: 1129.9; [121714-22-5]
Ubpbio Torin-1, 25MG
Torin 1-is a cell permeable highly potent, selective and ATP-competitive mTOR inhibitor of the mammalian target of rapamycin (mTOR) kinase. Torin-1 exhibits over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, as well as 450 other protein kinases. Torin-1 has been found to impair cell growth and proliferation through a mechanism involving mTORC1 inhibition other than mTORC2 inhibition, in which the rapamycin-resistant functions of mTORC1 is suppressed.
Ubpbio b-AP15, 2MG
b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death.
Medchemexpress LLC HY-100432 25mg Medchemexpress, LOC14 CAS:877963-94-5 Purity:>98%
Medchemexpress, HY-100432 25mg LOC14 CAS:877963-94-5 LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-100489 500mg Medchemexpress, TBHQ CAS:1948-33-0 Purity:>98%
Medchemexpress, HY-100489 500mg TBHQ CAS:1948-33-0 TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-107420 5mg Medchemexpress, AY 9944 CAS:366-93-8 Purity:>98%
Medchemexpress, HY-107420 5mg AY 9944 CAS:366-93-8 AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-108702 5mg Medchemexpress, ML-792 CAS:1644342-14-2 Purity:>98%
Medchemexpress, HY-108702 5mg ML-792 CAS:1644342-14-2 ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-108357 1mg Medchemexpress, 6-Diazo-5-oxo-L-nor-Leucine CAS:157-03-9 Purity:>98%
Medchemexpress, HY-108357 1mg 6-Diazo-5-oxo-L-nor-Leucine CAS:157-03-9 L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) is a glutaminases antagonist with a Ki of 6 μM. L-6-Diazo-5-oxonorleucine exhibits analgesic, antibacterial, antiviral and anticancer properties. L-6-Diazo-5-oxonorleucine displays genetic toxicity in vitro. L-6-Diazo-5-oxonorleucine decreases the self-renewal potential and metastatic ability of tumor cell[3][4]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.